Marquis^® (15% w/w ponazuril) Antiprotozoal Oral Paste

Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. For use only in horses. Not for use in horses intended for food.

The safe use of Marquis^® in horses used for breeding purposes, during pregnancy, or in lactating mares, has not been evaluated.

The safety of Marquis^® with concomitant therapies in horses has not been evaluated.

In field studies, blisters on the nose and mouth, skin rash or hives, loose stools, mild colic and seizure were observed. The association of these reactions to treatment was not established.

In animal safety studies, loose feces, sporadic inappetence, lost weight, and moderate edema in the uterine epithelium were observed.

Prior to treatment, EPM should be distinguished from other diseases that may cause ataxia in horses. Injuries or lameness may also complicate the evaluation of an animal with EPM. In most instances, ataxia due to EPM is asymmetrical and affects the hind limbs.

Clinicians should recognize that clearance of the parasite by ponazuril may not completely resolve the clinical signs attributed to the natural progression of the disease. The prognosis for animals treated for EPM may be dependent upon the severity of disease and the duration of the infection prior to treatment.

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